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Effectiveness and tolerability of every-other-day rosuvastatin dosing in patients with prior statin intolerance. Rosuvastatin: A high potency HMG-CoA reductase inhibitor. Statin Use and Cognitive Effects: Not a Brain Drain. Atorvastatin is a potent antihyperlipidemic but is quite expensive, costing up to $700 for a 1-year supply of 10-mg tablets in retail pharmacies. 3. Once-a-week rosuvastatin (2. 2012 Jan-Feb;6(1):93. doi: 10.1016/j.jacl.2011.09.002. Efficacy of Patient Aligned Care Team Pharmacist Services in Reaching Diabetes and Hyperlipidemia Treatment Goals. Clin Ther. Be diligent about putting back the nutrients that statins interfere with such as the coenzyme Q10, selenium, and vitamin K2, along with other heart healthy nutrients. Periodic rosuvastatin or atorvastatin dosing arrays (PRADA): patient-centered practice. Non-traditional dosing of statins in statin-intolerant patients-is it worth a try? Curr Atheroscler Rep. 2015;17(2):475. doi: 10.1007/s11883-014-0475-4. Am J Cardiol 2008;101:1747-1748. Rosuvastatin 5 and 10 mg/d: a pilot study of the effects in hypercholesterolemic adults unable to tolerate other statins and reach LDL cholesterol goals with nonstatin lipid-lowering therapies. Am J Cardiol 2009;103:393-394. 2010;10(6):383-400. doi: 10.2165/11204600-000000000-00000. Statins are typically very successful at lowering cholesterol, but they only work as long as you’re taking them. 2012 Apr 1;12(2):117-25. doi: 10.2165/11597940-000000000-00000. A significant difference in the mean percentage change in LDL from baseline for rosuvastatin vs. placebo was identified (12.2% reduction vs. 0.4% reduction, respectively; P = .002). Backes JM, et al. doi: 10.1371/currents.eogt.d21e7f0c58463571bb0d9d3a19b82203. Two of the 17 patients (11.8%) in the placebo treatment phase and three of the 15 patients (20%) in the rosuvastatin treatment phase experienced myalgias requiring cessation of therapy. Patients with lipid levels measured 1-3 days and 4-7 days after receiving their last rosuvastatin dose had similar mean LDL-C reductions. NIH “It’s important to note that atorvastatin and rosuvastatin really are the workhorses of cardiology and statins … Effectiveness and tolerability of every-other-day rosuvastatin dosing in patients with prior statin intolerance. Many patients who could benefit from hydroxymethylglutaryl coenzyme-A reductase inhibitors (statins) are unable to take statins because of myalgias while taking previous statin therapy. Two 8-week treatment phases consisted of rosuvastatin 5 mg once-weekly or matching placebo, with a dose titration to 10 mg once-weekly if not at LDL goal at week 4. PLoS Curr. Synopsis: Once-a-week rosuvastatin therapy was well tolerated in patients with a history of adverse events to one or more statins and led to significantly improved lipoprotein changes. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. J Am Pharm Assoc 2005;45: 503-513. One-year efficacy and safety of rosuvastatin + fenofibric acid combination therapy in patients with mixed dyslipidemia: evaluation of dose response. J Clin Lipidol. Glueck CJ, Aregawi D, Agloria M, Khalil Q, Winiarska M, Munjal J, Gogineni S, Wang P. Clin Ther. Efficacy and tolerability of once-weekly rosuvastatin in patients with previous statin intolerance. Patients tolerating the once-a-week dosing regimen experienced a 17% reduction in total cholesterol, a 23% reduction in LDL-C, a 12% reduction in triglycerides, and a 5% increase in high-density lipoprotein cholesterol (all significant, P < 0.001) during a mean follow-up period of 4 months. Set of features Karpman, MD, FACC, FACP, Clinical Professor of Medicine rosuvastatin placebo... Dr. Karpman reports no financial relationship to this field of study fenofibric acid combination in. 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