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[2] A 2005 Cochrane Review considered thirteen randomized clinical trials which assessed milk thistle in 915 patients with alcoholic and/or hepatitis B or C virus liver diseases. Originally a native of Southern Europe through to Asia, it is now found throughout the … : CD003620. It has been suggested that silymarin increases cell replication by 30%, which is related to 2 important components of silymarin: silybin and silychristin. (1791) In: Fruct. It has also been suggested that silymarin may diminish triglyceride synthesis in the liver.15, Lettéron et al studied the mechanisms of action of silymarin that provide protection against lipid peroxidation and the hepatotoxicity of carbon tetrachloride in mice, and they came to the conclusion that silymarin works by reducing metabolic activation by carbon tetrachloride and by acting as an antioxidant that prevents chain rupture.16, Other authors have shown that silymarin affords hepatoprotection against specific injury induced by microcystin (a hepatotoxin), paracetamol, halothane, and alloxan in several experimental models.17, Different researchers on live animals suggest that silymarin protects liver cells against different types of diseases including viruses, chemical substances, and natural toxic substances. Silybum marianum is a medicinal plant that has long been used as hepatoprotective remedy. English thesaurus is mainly derived from The Integral Dictionary (TID). Copyright © 2020 Multiply Media, LLC. This site uses cookies. It contains a variety of lignans, including silandrin, silybin, silychristin, silydianin, silymarin, and silymonin. = Carduus marianus L. blessed thistle, holy thistle, lady's thistle, milk thistle, Our Lady's mild thistle, Carduus marianus  (MeSH), Milk Thistle  (MeSH), plante : selon leurs propriétés (fr)[Classe...], asterid dicot genus - tracheophyte, vascular plant[Hyper. The medicinal parts of the plant are the ripe seeds. Silymarin decreases the enlarged liver by inhibiting 5-lipoxygenase cycle and inhibiting production of leukotrienes and free radicals in Kupffer cells of liver. Rambaldi A, Jacobs BP, Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. You've got the pronunciation of Silybum marianum right. Its half-life excretion is 6 hours. Most of documented data with Silybum marianum are about liver disorders; however, recently several beneficial properties on a wide variety of other disorders such as renal protection, hypolipidemic and anti-atherosclerosis activities, cardiovascular protection, prevention of insulin resistance, especially in cirrhotic patients, cancer, and Alzheimer prevention. Ro, Cookies help us deliver our services. This review article aims to present different aspects of Silybum marianum, especially the data in recently published articles about its effects on different diseases, apart from presenting the aspects of its hepatoprotection.6, Silybum marianum is of Asteriaceae family and has various other names including milk thistle, Marian thistle, Mary thistle, Mary’s thistle, Saint Mary’s thistle, Blessed milk thistle, Mediterranean milk thistle, variegated thistle, Cardus marianus, and Scotch thistle. Pre-inoculation of cancer cells with silybin before exposure to silybin led to increased Adriamycin effect in the prevention of cell growth.56, It should be noted that because of the strong antioxidant effects of Silybum marianum, there is a concern that this plant may produce interactions in fixing lymphocytotoxicity function of chemotherapy medicines acting through biochemical peroxidative paths. We recommend you to try Safari. However, silybin can strength cytotoxic cisplatin and doxorubicin synergestic interactions, and there is no evidence about its interaction with their cytotoxicity effect.57, Data from animal studies emphasize that silymarin can prevent carcinogenesis in epithelial tumors of different rat models. In Europe it is sown yearly in March-April. Please read and accept the terms and conditions and check the box to generate a sharing link. Who is the longest reigning WWE Champion of all time? The bracts are hairless, with triangular, spine-edged appendages, tipped with a stout yellow spine. Crowdsourced audio pronunciation dictionary for 89 languages, with meanings, synonyms, sentence usages, translations and much more. Another plant (Silybum marianum) called milk thistle in English is called silbiin maryamii in Arabic. Silibinin (syn. Furthermore, they vary based on the type and severity of the condition of treatment and even the patient’s individual characteristics. Silymarin (and especially silybin) is a powerful antioxidant and free radical scavenger that restores a lot of internal antioxidants and prevents oxidative stress.72, Oxidative stress has been shown to be implicated in a wide range of pathological conditions such as chronic inflammation and the generation of damage, particularly during ischemia/reperfusion,73,74 neurological disorders,75,76 diabetes,77,78 atherosclerosis,79,80 cardiovascular diseases,81,82 cancer,83,84 gastrointestinal,85,86 and infectious,86–88 diseases or wound complication.89,90 These conditions involve many changes such as alterations in redox stat.91–94 Antioxidants possess the ability to counteract these conditions.64,66,92.

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